051117 - "One-time stressors" in early childhood
In this email of November 17, 2005, I provide FSU's medical school's dean and the President and over 150 other FSU medical and law school personnel with new scientific informationabout the detrimental effects on adolescents of "one-time stress" in infancy and early childhood, its significance for the issue of infant and early childhood circumcision, and I continue to call for an urgent conference at FSU on circumcising infants and children. - VL
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Dr. Ocie Harris, Dean
School of Medicine
Florida State University
Dr. Thomas Wetherell, President
Florida State University
Dr. Lawrence G. Abele, Provost
Florida State University
Dear Dean Harris, President Wetherell, and Provost Abele:
Please read and understand this new and important scientific research (copied below this email) on ”one-time stress” in infancy and early childhood and its negative impact on mental health in adolescence. Here is the url.
http://www.ohsu.edu/ohsuedu/newspub/releases/111605stress.cfm
or
http://tinyurl.com/azffv
I believe this important scientific research is telling us that anyone who will submit a human male infant to the one-time stress of medically unnecessary, nontherapeutic, elective infant circumcision is asking for potentially serious emotional, intellectual and social trouble during the adolescence of that male child and probably later in his life as well.
Do “school shootings” ring any bells here? Do high rates of US domestic violence by adolescent and adult men against women and children, and violence against each other, ring any bells here?
The USA is the ONLY NATION IN THE WORLD where the medical profession circumcises the majority of infant males. Infant circumcision is where sex and violence first meet, and marry. Infant circumcision IS sexual violence, of the grossest kind, but it goes beyond most sexual violence into permanent sexual mutilation as well. http://research.cirp.org
Please get literate on this subject ASAP. Our society’s and this planet’s future human health and happiness depend utterly upon adults taking adult responsibility to protect all children from all unnecessary trauma and mutilation in childhood, especially early childhood and infancy, and especially sexual/genital trauma and mutilation. Dean Harris, President Wetherell, Provost Abele, do your important parts.
In general, the earlier in the lives of children one-time traumas and mutilations occur the more serious the negative consequences for human brain development and future mental health. This is not new information. Sigmund Freud knew it and said so explicitly early in the 20th century.
It is also common sense that early trauma in the life of any organism is potentially more damaging than later trauma, as evidenced by expressions in our language that you have known since childhood, aphorisms such as, “As the twig is bent so grows the tree”, but the neuroanatomical brain development involved is just beginning to be explicated and understood scientifically. Read additional modern science about developmental brain damage from trauma - physical or emotional - during infancy and early childhood:
"Brain Damage Linked to Child Abuse..."
http://mcleanhospital.org/PublicAffairs/20001214_child_abuse.htm
"Male neonatal circumcision and brain damage"
http://cirp.org/library/psych/brain_damage/index.html
"How Culture Shapes the Developing Brain"
http://MontaguNOCIRCpetition.org/pdf/culture_brain-ttf_spring_2002.pdf
That the scientific neuroanatomy lags behind common human understanding is not surprising, and is no excuse for adults not taking up the vitally important cause of protecting ALL children and infants from medically unnecessary trauma and mutilation of ALL kinds.
Please respond appropriately to this new science. I ask you three again to call a local review at the FSU Medical School of the information, scientific and otherwise, now available on unnecessary human genital cutting, trauma and mutilation of children by adults. This conference should be wide-ranging and welcome all viewpoints on this issue. No one with anything to say about it should be excluded.
When I was arrested and jailed 35 years ago in Tallahassee for protesting peacefully on the public sidewalk outside Tallahassee Memorial Hospital against infant circumcision, ignorance of these matters was perhaps a (barely) credible excuse for not taking responsible adult action to protect human babies and children from medically unnecessary genital cutting, trauma and mutilation. That is no longer the case. No excuse for unnecessary, elective child sexual abuse is good enough today.
Please get back to me as soon as possible about the upcoming FSU Medical School local conference on infant circumcision. Killing children, and unnecessarily amputating and thereby killing any healthy, normal, living body part of any child, is unacceptable adult misbehavior. Standing back and doing nothing about other adults killing children or any healthy, normal, living body part of any child unnecessarily is also unacceptable adult misbehavior. I do not accept either of these adult misbehaviors in any of you three or in any other adult. No excuse is good enough for anyone to kill any child or to amputate and kill unnecessarily any healthy, living body part of any child or to sit silently by while other adults misbehave in this potentially lethal and always damaging way.
Van Lewis
P.O. Box 323
Panacea, Florida 32346
850-697-3857
vanlewis@post.harvard.edu
PS – For important scientific research preceding this new research and going all the way back to the 1950s, see http://violence.de. The gross irresponsibility of the US medical community, including you, Dean Harris, on this issue is not a new thing. It has been going on for many decades. Some people accept it as normal medical behavior. I do not. There is something seriously wrong with medicine in its unwillingness and apparent inability to correct its own mistakes, even when they become glaring. Study Ignaz Semmelweis MD and the medical history surrounding purpureal fever aka “childbed fever” for a classic example of what we are up against in US medicine with the extremely serious infant and child circumcision issue. A book was recently published by a US physician that blamed SEMMELWEIS for medicine’s refusal for 50 years to institute simple hygienic procedures that prevented childbed fever. Doctors refused for over 50 years to wash their hands between patients, and thereby unnecessarily killed tens or hundreds of thousands of women and children, rather than listen to Semmelweis. And now doctors say this unnecessary and tragic delay was all Semmelweis’s fault! The same thing is happening again with infant circumcision, only it’s taken over 150 years so far with no end yet in sight. I have no doubt whatever that when it’s all over circumcisers will blame the people who objected to this insanity for the unnecessary and tragic delay in medically unnecessary circumcision’s long-overdue abolition. Responsibility for that delay belongs to US medicine, among others, including FSU’s School of Medicine, as does responsibility for adopting this stone-age insanity as medicine in the first place. It’s called “irresponsibility” and US medicine runs on it.
cc: Broad public dissemination
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From: Van Lewis
Date: Thu, 17 Nov 2005 08:50:33 -0800
To:
Subject: "One-time stressors" in early childhood
Judy Cameron, Ph.D.
Senior Scientist - Oregon Regional Primate Research Center
Professor of Physiology and Pharmacology
Professor of Obstetrics and Gynecology
Professor of Behavioral Neuroscience
Oregon Health & Science University
Jim Dahl, M.D.
Staunton Professor, Pediatrics & Psychiatry
University of Pittsburgh
Jim Newman
OHSU
Dear Professors Cameron, Dahl, and Jim Newman:
Please try infant circumcision as the “one-time stress” in your important experiments with rhesus macaque monkeys.
Van Lewis
P.O. Box 323
Panacea, Florida 32346
850-697-3857
vanlewis@post.harvard.edu
http://www.ohsu.edu/ohsuedu/newspub/releases/111605stress.cfm
or
http://tinyurl.com/azffv
News and Information
November 16, 2005
Contact: Jim Newman
503-494-8231
Email Jim Newman
OHSU Research Reveals Likely Connection Between Early-Life Stress And Mental Health Problems During The Teenage Years (November 16, 2005)
Research to be presented Wednesday, Nov. 16, at the Society for Neuroscience Meeting in Washington, D.C.
WASHINGTON, D.C. - Research conducted at the Oregon National Primate Research Center at Oregon Health & Science University and at the University of Pittsburgh suggests a strong link between significant stress early in life and the increased incidence of mental health problems during adolescence. The research strengthens the case for proactive treatment or counseling of children who undergo a significant early-life stress. The research is being presented during the Society for Neuroscience meeting in Washington, D.C., Nov. 12-16. The meeting is one of the largest and most respected gatherings of neuroscientists in the world.
Both past research and human observation reveal that children who experience early-life stresses such as abuse, neglect, or loss of a parent have an increased risk of developing attachment disorders. Later in childhood, these same children show an increased incidence of manifesting some types of behavioral and emotional disorders, including attention deficit/hyperactivity disorder, conduct disorders, anxiety, depression, suicide, drug abuse and post-traumatic stress disorder. Both genetic factors and life experiences appear to play a role in the causes of these mental health disorders.
"Until now only human observation and theories have suggested that early-life stresses can also lead to problems as far away as the teenage years," said Judy Cameron, Ph.D., a senior scientist in the divisions of Reproductive Sciences and Neuroscience at the OHSU Oregon National Primate Research Center. Cameron also is a professor of psychiatry at the University of Pittsburgh. "By studying a species that has responses to early-life stresses that are very similar to young children, we can get a developmental picture that is much clearer than in humans."
Interpretation of human epidemiological studies are often difficult because children experiencing early-life stresses frequently have exposure to many other situations, such as ongoing mental or physical abuse or neglect, both of which can increase the incidence of mental health problems. In contrast, for this study researchers were able to rear rhesus macaque monkeys with a one-time stress exposure, followed by rearing in a very stable social environment. The findings provide strong evidence that stress exposure early in life can have dramatic, long-lasting effects that persist into the teenage years and perhaps even adulthood, even in the face of an otherwise stable rearing, such as would be recommended for children experiencing early life stresses.
"Some of the most important clinical questions targeting early intervention for behavioral and emotional problems in youth will require a deeper understanding of the unique vulnerabilities linked to neural changes at puberty and adolescence - and more specifically, how these adolescent changes interact with earlier vulnerabilities such as major life stressors and social adversity early in life," said Ronald E. Dahl, M.D., the Staunton Professor of Psychiatry and Pediatrics at the University of Pittsburgh. "This line of study by the Cameron lab is providing unique insights into these developmental interactions in ways that can not be achieved in controlled studies in humans."
The researchers studied 16 small social groups of monkeys for a three year period. Because monkeys mature at a much more accelerated pace than humans, a monkey 2 to 4 years old would correspond to a human teenager in regard to mental and physical development. To ascertain the impacts of an early-life stress, certain monkeys had their mothers removed from the social group at various stages early in life. These monkeys continued to be raised in the stable social groups with other monkeys - similar to a human child that loses a parent but continues to be raised in their family. Some infant monkeys had their mothers removed from the social group when they were 1 week old. These infants went on to be alert and active, but to show less than normal interest in social interactions. Their behavior looked similar to children who develop a form of attachment disorder characterized by withdrawal from social interactions. Some infant monkeys had their mothers removed from the social group when they were 1 month old. These infants went on to show increased clinginess and seek social comfort more than normal. Their behavior looked similar to children who develop a form of attachment disorder characterized by indiscriminate clinginess.
In adolescence, one-week separated monkeys continued to spend less time in social contact with other monkeys, and showed more time displaying self-comforting behaviors, such as snuggling a toy or even sucking their thumb, especially when they were placed in mildly stressful situations. In adolescence they also showed less inclination to explore novel, interesting situations - this has been taken as a marker of anxiety in human studies. In contrast, adolescent monkeys who had experienced maternal separation at 1 month old continued to show significantly more time in social contact compared to monkeys not experiencing the stress of early maternal separation. However, they also developed several new behavioral characteristics in adolescence. Like one-week separated monkeys they, too, developed a reduced inclination to explore novel, interesting situations. And, they also developed "freezing" behavior in response to fearful stimuli - again a characteristic of increased anxiety in humans.
"Why there is an increase in the expression of anxious behaviors in individuals experiencing early-life stress during puberty remains unknown," said Cameron. "However, we now know this occurs both in humans and in nonhuman primates. We hope that the increased ability to study behavior and pubertal development in nonhuman primates will allow us to more thoroughly address this issue. We can speculate that hormonal changes that occur with puberty interact with the neural circuits whose function is modulated by early-life stress, but identifying such potential mechanisms will take further work. We are encouraged that the nonhuman primate model will allow this type of study."
Another issue that has been raised in clinical studies of children experiencing early life stress, is whether the timing of puberty is affected by such stress exposure. Girls experiencing sexual abuse early in life have been reported to go through puberty at earlier ages than non-abused girls. However, in this report, the researchers tracked reproductive hormones and the incidence of menstrual bleeding in female monkeys throughout puberty and found that there were no differences in the timing of puberty onset in animals that had experienced early-life stress compared to control animals. This finding suggests that early puberty onset may not be a response to all types of early-life stress, but may be more specific to girls experiencing early sexual abuse.
Support for this research was contributed by the John D. & Catherine T. MacArthur Foundation.
The ONPRC is a registered research institution, inspected regularly by the United States Department of Agriculture. It operates in compliance with the Animal Welfare Act and has an assurance of regulatory compliance on file with the National Institutes of Health. The ONPRC also participates in the voluntary accreditation program overseen by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC).
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